Laser Speckle Perfusion Imaging (LSPI)

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Laser Speckle Perfusion Imaging (LSPI) 

The technique works by illuminating an area of tissue with laser light to produce a high contrast random interference effect known as a speckle pattern. Blood cells flowing through the region of interest cause the speckle pattern to change and appear blurred, which leads to a reduction in local contrast. High flow rates show up as areas of low contrast and conversely, low flow rates are defined by regions of high contrast.